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Lentiviral Integration Risk Track (2D)

A 2D linear genome-track map of lentiviral vector integration: watch a weighted landing distribution, a live risk histogram and a running clonal-dominance-risk time series, driven by the same activity-weighted integration and genotoxicity math as the 3D chromatin-loop simulator.

Rare Disease & Gene Therapy2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

Details

CategoryRare Disease & Gene Therapy

RenderingCanvas 2D

DifficultyAdvanced

Target FPS60

ControlsToggle SIN vs LTR-intact vector design, adjust residual LTR enhancer strength, target-cell proliferation pressure, and vector dose per batch, then click Fire Vector Batch to drop particles onto a linear 48-locus genome track and watch live integration, genotoxic-hit, and clonal-dominance-risk readouts update alongside a running risk time-series chart.

gene therapylentivirusinsertional mutagenesisvector safetygenotoxicitySIN vectorgenome trackrisk time series

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The same integration-site genotoxicity model as the 3D chromatin-loop simulator, rendered as a flat genome track instead of a rotating 3D ring: a horizontal ruler of 48 discretised loci (four flagged as proto-oncogene TSS zones) with a live falling-capsid animation, a stacked lollipop plot of every landing site, and a running time-series chart of clonal-dominance risk. Toggle between a modern SIN (self-inactivating) vector design and a historical LTR-intact design to see, event by event, why the self-inactivating architecture became the clinical standard after the earliest gammaretroviral trials caused insertional leukemogenesis.

⚙ Under the hood

A 2D linear genome-track map of lentiviral vector integration: watch falling capsids land on a weighted-random locus, stack into a lollipop plot of safe vs genotoxic hits, and a live time-series chart trace the running clonal-dominance risk, all driven by the same activity-weighted integration probability and LTR-enhancer risk formulas as the 3D chromatin-loop simulator.

gene therapylentivirusinsertional mutagenesisvector safetygenotoxicitySIN vectorgenome trackrisk time series

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install