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Lentiviral Vector Integration-Site Genotoxicity Simulator

Fire lentiviral gene-therapy vectors into a 3D chromatin loop and watch where they integrate. Compare SIN (self-inactivating) vs LTR-intact vector design and see how proximity to proto-oncogene loci drives insertional-mutagenesis and clonal-dominance risk.

Rare Disease & Gene Therapy3DAdvanced60 FPS

Every integrating gene-therapy vector faces the same structural safety question: where in the genome does it land, and what happens if it lands next to the wrong gene? This simulator renders a chromatin loop in 3D with 48 discretised loci, four of them flagged as proto-oncogene TSS zones, and fires batches of lentiviral vector particles that integrate with a realistic bias toward transcriptionally active regions. Each landing site's genotoxic risk is computed live from the vector's LTR enhancer strength and its distance to the nearest oncogene — toggle between a modern SIN (self-inactivating) design and a historical LTR-intact design to see, in real time, why the self-inactivating architecture became the clinical standard after the earliest gammaretroviral trials caused insertional leukemogenesis.

⚙ Under the hood

Fire lentiviral gene-therapy vector batches into a 3D chromatin loop and watch where they integrate, comparing modern SIN vector design against historical LTR-intact vectors and their insertional-mutagenesis risk near proto-oncogene loci.

gene therapylentivirusinsertional mutagenesisvector safetygenotoxicitySIN vector

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install