PEGylated LNP Antibody Clearance — 2D Pharmacokinetic Simulator

PEGylated lipid nanoparticles are the delivery vehicle behind most clinical CRISPR and mRNA therapeutics, but their stealth coating is a double-edged sword: PEG itself provokes an anti-PEG antibody response that can neutralize the benefit on a second dose. This 2D simulator pairs a rotatable circulation-loop diagram — LNPs recirculating past a Kupffer-macrophage zone and a hepatocyte-target zone — with a live concentration-over-time chart plotting the exact closed-form pharmacokinetic solution: antibody titer, PEG density, and macrophage activity feed a Hill-function clearance rate that competes against a constant target-uptake rate for every circulating particle. Prime a naive dose, watch the antibody titer rise, then re-dose to see the Accelerated Blood Clearance phenomenon collapse the delivered payload in real time, with live blood concentration, half-life, and delivered-dose readouts tracking the underlying formula exactly.