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ESCRT-Mediated Exosome Biogenesis & Receptor Signaling

Interactive 3D model of exosome-mediated cell signaling: ESCRT-III drives intraluminal vesicle budding inside a multivesicular body, exosomes cross the extracellular space, and mass-action receptor binding on a recipient cell drives a Hill-function downstream signal.

Molecular Biology3DAdvanced60 FPS📱 Mobile-adapted⇄ 2D version

This simulation follows the full exosome-mediated signaling pathway in 3D: inside a donor cell's late endosome, ESCRT-III filaments constrict budding necks until membrane scission releases intraluminal vesicles into a multivesicular body; the MVB periodically fuses with the plasma membrane, releasing exosomes that drift across the extracellular space; and on arrival at a recipient cell, surface ligands bind membrane receptors under real mass-action kinetics, driving an ultrasensitive Hill-function downstream signal. Tune ESCRT constriction rate, ligand density, transport speed and receptor off-rate, and watch exosome output, receptor occupancy and signal amplitude respond live.

⚙ Under the hood

Watch ESCRT-III constrict budding necks to release intraluminal vesicles inside a multivesicular body, exosomes cross the extracellular space, and mass-action receptor binding on a recipient cell drives an ultrasensitive downstream signal.

exosomesESCRTcell signalingreceptor kineticsmultivesicular bodymolecular biology

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install