Home▸Molecular Biology▸Exosome Signaling: Ligand Diffusion & Receptor Kinetics (2D)

Exosome Signaling — 2D Ligand Field & Receptor-Occupancy Model

2D field simulation of exosome-mediated cell signaling: ESCRT-III neck constriction, an advection-diffusion ligand concentration field crossing the extracellular space, and a deterministic mass-action receptor-occupancy ODE driving a Hill-function downstream signal.

Molecular Biology2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

This companion view represents the same ESCRT-mediated exosome pathway as a set of 2D fields instead of 3D particles: budding necks on a donor-cell cross-section still constrict and undergo scission exactly as in the 3D model, but every released exosome now injects ligand mass into a 1D advection-diffusion-decay concentration field that crosses the extracellular space toward a recipient-cell cross-section. Receptor occupancy on the recipient is integrated directly from the mass-action ODE (a deterministic mean-field solve, not a per-particle Monte-Carlo simulation), and the same ultrasensitive Hill function converts occupancy into a downstream signal. Tune ESCRT constriction rate, ligand density, transport speed and receptor off-rate and watch the field profile, occupancy and signal respond live.

⚙ Under the hood

A 2D field-based counterpart to the 3D exosome signaling simulation: ESCRT-III necks constrict and undergo scission by the same rate law, but each released exosome now injects ligand mass into a 1D advection-diffusion-decay concentration field crossing the extracellular space, and recipient receptor occupancy is integrated directly from the deterministic mass-action ODE driving the same Hill-function downstream signal.

exosomesESCRTcell signalingreceptor kineticsreaction-diffusionmolecular biology

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install