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SELEX 2D: Affinity Distribution Selection

2D SELEX simulator: watch a random-sequence oligonucleotide library's affinity distribution evolve on a live Langmuir-isotherm / survival-probability chart and a per-round dot-histogram of every aptamer's dissociation constant, across rounds of stringent partitioning and mutagenic PCR amplification.

Molecular Biology2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

SELEX is the directed-evolution process used to discover DNA/RNA aptamers — folded nucleic-acid ligands that bind a target with antibody-like specificity. This 2D simulator models the same library of 260 candidate sequences and the same Langmuir-isotherm binding, stochastic stringent partitioning, and mutagenic PCR amplification as the 3D version, but plots the population directly in affinity space: a live isotherm/survival-probability curve on top, and a per-round dot histogram of every aptamer's K_d on the bottom. Tune the target concentration, wash stringency and mutation rate, run rounds one at a time or on auto-play, and watch the histogram collapse toward tight binders exactly as the affinity distribution does on the bench.

⚙ Under the hood

Watch a random-sequence oligonucleotide library evolve against a molecular target on a live Langmuir-isotherm / survival-probability chart and a per-round dot histogram of every aptamer's dissociation constant — the same stochastic partitioning and mutagenic PCR amplification as a real SELEX protocol, read here directly in affinity space instead of as an orbiting cloud.

aptamerSELEXmolecular biologyPCRbinding affinitydirected evolution2D

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install