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AAV Biodistribution 2D: Mean-Field Tropism Flow Model

2D compartmental flow-network model of AAV gene-therapy biodistribution: a continuous mass-action ODE (not a per-particle random walk) pushes circulating dose through liver, muscle, heart and CNS compartments at serotype-specific capture rates — drag/zoom the flow diagram and watch a live population time-series.

Molecular Biology2DModerate60 FPS📱 Mobile-adapted⇄ 3D version

Where an injected AAV gene-therapy dose ends up is set by receptor-driven tropism, not by where the needle goes in. This 2D view treats the whole dose as a continuous mass flowing through a four-compartment network — liver, skeletal muscle, heart and CNS hanging off a shared circulation hub — and integrates a mass-action ODE system live (RK4, not a per-particle random walk) so the flow diagram's animated edges and the stacked time-series panel show the exact deterministic large-dose limit of the same serotype-specific capture kinetics. Switch capsid serotype or injection route and watch the steady-state split between liver sequestration and on-target delivery converge to the analytic pᵢ·κᵢ/Σⱼpⱼ(κⱼ+(1−κⱼ)c) limit in real time.

⚙ Under the hood

A 2D compartmental flow-network model of AAV gene-therapy biodistribution: a continuous mass-action ODE, integrated live with RK4, pushes circulating dose through liver, muscle, heart and CNS compartments at serotype-specific capture rates, converging to the same analytic steady-state split between liver sequestration and target delivery as the discrete per-particle picture.

gene therapyAAVviral vectortropismpharmacokineticsmolecular biologyODE modelcompartmental model

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install