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💀 Apoptosis: Intrinsic vs Extrinsic Pathway Simulator

Watch how death-receptor signals and mitochondrial cytochrome-c release converge on a caspase amplification cascade that decides whether a cell lives or dies.

Medicine & Biophysics3DModerate60 FPS

The simulation shows how death-receptor signaling and mitochondrial cytochrome-c release each activate initiator caspases that converge on a shared, amplifying executioner caspase cascade determining the cell's fate.

🔬 What It Demonstrates

🎮 How to Use

Trigger the extrinsic pathway by activating death receptors or the intrinsic pathway by shifting the Bcl-2 family balance, then watch the caspase cascade amplify in the 3D view as it crosses the point of no return.

💡 Did You Know?

A human adult loses roughly fifty to seventy billion cells to programmed cell death every single day, a routine turnover roughly equal to the body's entire cell count over a couple of months.

⚙ Under the hood

Watch how death-receptor signals and mitochondrial cytochrome-c release converge on a caspase amplification cascade that decides whether a cell lives or dies.

apoptosiscell deathcaspasesmitochondriacytochrome cdeath receptorscell biologycancer biology

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install