The simulation shows how death-receptor signaling and mitochondrial cytochrome-c release each activate initiator caspases that converge on a shared, amplifying executioner caspase cascade determining the cell's fate.
Trigger the extrinsic pathway by activating death receptors or the intrinsic pathway by shifting the Bcl-2 family balance, then watch the caspase cascade amplify in the 3D view as it crosses the point of no return.
Toggle switches for extrinsic death-receptor activation and intrinsic stress signals, with a rotatable 3D caspase cascade view
A human adult loses roughly fifty to seventy billion cells to programmed cell death every single day, a routine turnover roughly equal to the body's entire cell count over a couple of months.
The simulation shows how death-receptor signaling and mitochondrial cytochrome-c release each activate initiator caspases that converge on a shared, amplifying executioner caspase cascade determining the cell's fate.
The simulation shows how death-receptor signaling and mitochondrial cytochrome-c release each activate initiator caspases that converge on a shared, amplifying executioner caspase cascade determining the cell's fate.
Trigger the extrinsic pathway by activating death receptors or the intrinsic pathway by shifting the Bcl-2 family balance, then watch the caspase cascade amplify in the 3D view as it crosses the point of no return.
A human adult loses roughly fifty to seventy billion cells to programmed cell death every single day, a routine turnover roughly equal to the body's entire cell count over a couple of months.