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🏭 Unfolded Protein Response and ER Stress Simulator

Watch misfolded proteins accumulate in the endoplasmic reticulum until sensor proteins IRE1, PERK, and ATF6 trigger the unfolded protein response, and control the stress load that decides adaptive recovery versus apoptotic shutdown.

Medicine & Biophysics3DModerate60 FPS

The simulation shows misfolded proteins accumulating inside a virtual ER until IRE1, PERK, and ATF6 sensors activate, letting you control stress load to see the transition from adaptive recovery to apoptotic shutdown.

🔬 What It Demonstrates

🎮 How to Use

Increase the misfolded protein load slider to stress the virtual ER and watch each sensor pathway light up in sequence, then push stress past the recovery threshold to trigger the switch into the apoptotic response.

💡 Did You Know?

IRE1 activates a form of mRNA splicing that happens entirely outside the nucleus in the cytoplasm, a discovery that revealed a completely novel mechanism of gene regulation controlled directly by stress inside an organelle.

⚙ Under the hood

cell biologyendoplasmic reticulumunfolded protein responseer stresscellular stress responseapoptosisprotein foldingmolecular biology

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install