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🔥 Cytokine Storm Cascade in Severe Infection

Explore how IL-6 and TNF-alpha released from immune cells can create a runaway positive-feedback loop, recruiting ever more immune cells past a dangerous threshold.

Medicine & Biophysics3DModerate60 FPS💨 Air & Wind

The simulation models how immune cell activation releases IL-6 and TNF-alpha that recruit further immune cells, showing how the resulting positive-feedback loop either resolves naturally or crosses a runaway threshold.

🔬 What It Demonstrates

🎮 How to Use

Adjust the initial trigger strength and the negative-feedback strength sliders to see whether the cytokine cascade settles back to baseline or spirals past the runaway threshold in the 3D visualization.

💡 Did You Know?

The interleukin-6 blocking drug tocilizumab was originally developed for rheumatoid arthritis decades before it became a standard treatment for cytokine release syndrome caused by CAR-T cancer therapy.

⚙ Under the hood

Explore how IL-6 and TNF-alpha released from immune cells can create a runaway positive-feedback loop, recruiting ever more immune cells past a dangerous threshold.

cytokine stormimmunologyil-6tnf-alphainflammationsepsispositive feedbackimmune response

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install