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Accelerated Blood Clearance of PEGylated CRISPR LNPs

Interactive 3D pharmacokinetic simulator of anti-PEG antibody-driven Accelerated Blood Clearance (ABC): watch redosed CRISPR lipid nanoparticles get opsonized by Kupffer cells before they can reach hepatocytes.

Rare Disease & Gene Therapy3DAdvanced60 FPS

PEGylated lipid nanoparticles are the delivery vehicle behind most clinical CRISPR and mRNA therapeutics, but their stealth coating is a double-edged sword: PEG itself provokes an anti-PEG antibody response that can neutralize the benefit on a second dose. This simulator renders a 3D liver sinusoid loop where CRISPR-carrying LNPs recirculate past Kupffer macrophages and hepatocyte targets, driven by a real competing first-order pharmacokinetic model — antibody titer, PEG density, and macrophage activity feed a Hill-function clearance rate that competes against a constant target-uptake rate for every circulating particle. Prime a naive dose, watch the antibody titer rise, then re-dose to see the Accelerated Blood Clearance phenomenon collapse the delivered payload in real time, with live blood concentration, half-life, and delivered-dose readouts tracking the underlying formula exactly.

⚙ Under the hood

Interactive 3D pharmacokinetic simulator of anti-PEG antibody-driven Accelerated Blood Clearance: watch redosed CRISPR lipid nanoparticles get opsonized by Kupffer cells before they can reach hepatocytes.

CRISPRgene therapylipid nanoparticlepharmacokineticsimmunogenicitydrug delivery

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install