SLCO1B1 Transporter & Statin Myopathy Risk Simulator

The gene SLCO1B1 encodes OATP1B1, the hepatic transporter that pulls statins out of the bloodstream and into the liver for clearance. Its common reduced-function variant is the single strongest known genetic risk factor for statin-induced muscle toxicity, especially with simvastatin. This simulator models the underlying pharmacokinetics as a first-order elimination process gated by transporter function, drug dependence on that transporter, and repeated dosing, while a 3D bloodstream loop visualizes statin molecules being captured by the liver or left circulating past muscle tissue whose glow tracks accumulating myopathy risk. Pick a genotype, choose a statin, dose the patient, and watch plasma concentration, cumulative exposure and risk evolve in real time.