NAT2 Acetylator Phenotype Simulator

A single gene, NAT2, decides how fast your liver clears the tuberculosis drug isoniazid — and getting it wrong is a textbook pharmacogenomics failure: too slow and the drug accumulates toward nerve-damaging peripheral neuropathy, too fast (relative to a fixed dose) and levels never climb high enough to work. This simulator renders isoniazid as a population of particles circulating through a 3D bloodstream loop and being converted by an instanced liver-cell lattice at a rate set by your chosen NAT2 genotype — rapid, intermediate, or slow acetylator — using the real one-compartment first-order pharmacokinetic model. Adjust the daily dose and simulation speed, pause or resume dosing, and watch the live plasma-concentration chart, half-life, and steady-state accumulation ratio update exactly as the exponential decay equation predicts.