SLCO1B1 Transporter & Statin Myopathy Risk Simulator

SLCO1B1 Genotype

Wild-type — normal OATP1B1 hepatic uptake. Reference clearance.

Statin

Oral dose 40 mg

Live Readouts

Plasma concentration0.0 mg/L

Cumulative AUC exposure0

Myopathy risk0.0%

How it works

OATP1B1, encoded by SLCO1B1, is the main transporter that pulls statins out of the blood and into hepatocytes for metabolism and biliary excretion. The common reduced-function allele (rs4149056, c.521T>C) slows this uptake, so the drug lingers in plasma — clinically this is the strongest known genetic predictor of simvastatin-induced myopathy (SEARCH trial, CPIC guideline).

dC/dt = -k_elim · C
k_elim = k_base · [1 - (1-g)·d] + k_renal
AUC(t) = ∫ C dt
Risk  = 100 · (1 - e^(-AUC/τ))

Here g is the genotype's relative transporter function (TT=1.0, TC≈0.65, CC≈0.35), d is how OATP1B1-dependent the chosen statin's clearance is (simvastatin high, rosuvastatin lower — it leans more on other pathways), and k_renal is a small genotype-independent clearance floor. A poor-function CC patient on simvastatin clears the drug slowly, so each dose stacks on top of the last, cumulative AUC climbs, and myopathy risk rises toward saturation.

Genotype buttons — set the transporter function factor g.
Statin buttons — set how OATP1B1-dependent clearance is (d) and the risk time-constant τ.
Dose slider + Administer Dose — adds a bolus to plasma concentration; click repeatedly to simulate repeated daily dosing and watch accumulation.
Particles — statin molecules flow from the gut into the bloodstream loop; the liver's transporter ring captures them at a rate set by k_elim, while uncaptured molecules keep circulating past the muscle tissue, whose glow tracks accumulated risk.

Statin molecule Liver / OATP1B1 transporter Muscle tissue (myopathy risk)

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