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Biodegradable Implant Drug Elution

Interactive 3D model of drug release from a biodegradable polymer implant: Fickian diffusion of drug particles coupled to first-order polymer hydrolysis, with a live cumulative-release curve.

Molecular Biology3DModerate60 FPS📱 Mobile-adapted⇄ 2D version

This simulator models how a drug escapes a biodegradable polymer implant such as a PLGA microsphere or rod. Hundreds of drug particles are seeded through a translucent 3D matrix and undergo a Fickian random walk with a diffusion coefficient that is not fixed: as the polymer backbone hydrolyses over simulated days, its average molecular weight decays exponentially and the effective diffusivity ramps up, reproducing the biphasic burst-then-erosion release profile seen in real biodegradable depots. Adjust the intrinsic diffusion coefficient, the hydrolysis rate constant, the erosion–diffusivity coupling strength, and the drug loading, and watch the live cumulative-release curve build in real time.

⚙ Under the hood

Watch drug particles diffuse out of a biodegradable polymer implant while the matrix itself hydrolyses, coupling Fickian diffusion to a rising effective diffusivity and producing a live cumulative-release curve.

drug deliverybiodegradable polymerPLGAdiffusionhydrolysispharmacokinetics

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install