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Pituitary-Thyroid Feedback Axis

Interactive 3D pituitary-thyroid negative-feedback simulator: compare a healthy TSH/T4 loop against primary hypothyroidism (failing thyroid, high TSH) and secondary hypothyroidism (failing pituitary, low TSH) to see how the TSH/T4 pattern pinpoints which gland is malfunctioning.

Medicine & Biophysics3DModerate60 FPS

Watch the pituitary-thyroid negative-feedback loop run live in 3D: TSH pulses travel from the pituitary down to the thyroid, T4 pulses travel back up, and the pituitary continuously adjusts its own TSH output based on the T4 level it senses. Switch scenarios to see how a healthy loop self-stabilizes, how a failing thyroid gland produces the classic high-TSH/low-T4 pattern of primary hypothyroidism, and how a failing pituitary gland produces the low-TSH/low-T4 pattern of secondary hypothyroidism — the same low-T4 outcome with opposite TSH signatures depending on which gland is actually broken.

⚙ Under the hood

Watch a live 3D pituitary-thyroid negative-feedback loop and compare a healthy TSH/T4 axis against primary hypothyroidism (failing thyroid, high TSH) and secondary hypothyroidism (failing pituitary, low TSH) to see how the TSH/T4 pattern reveals which gland is malfunctioning.

endocrinologythyroidpituitaryTSHT4hypothyroidismnegative feedbackhormone axismedicine

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install