Home▸Medical Technology & Imaging Physics▸The Growth Hormone Feedback Loop: GHRH, Somatostatin and IGF-1

📈 The Growth Hormone Feedback Loop: GHRH, Somatostatin and IGF-1

Explore how the hypothalamus, pituitary, and liver work together in a push-pull loop of GHRH, somatostatin, growth hormone, and IGF-1 to regulate growth and metabolism.

Medical Technology & Imaging Physics3DModerate60 FPS

This simulator demonstrates how GHRH and somatostatin interact to produce pulsatile GH secretion, how GH drives hepatic IGF-1 production, and how IGF-1 feeds back to regulate the hypothalamus and pituitary.

🔬 What It Demonstrates

🎮 How to Use

Adjust the GHRH and somatostatin signal strengths to see how pituitary GH output, sleep-related pulses, and downstream IGF-1 levels change in real time, then observe how feedback loops readjust the system.

💡 Did You Know?

Did you know that roughly 70% of a person's daily growth hormone output is released during the first few hours of deep sleep, which is one reason chronic sleep deprivation in children has been linked to slowed growth?

⚙ Under the hood

Explore how the hypothalamus, pituitary, and liver work together in a push-pull loop of GHRH, somatostatin, growth hormone, and IGF-1 to regulate growth and metabolism.

growth hormoneigf-1hypothalamuspituitaryendocrinologysomatostatinacromegalyphysiology

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install