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Blood-Brain Barrier Drug Crossing Simulator

Interactive 3D blood-brain barrier simulator: tune a drug candidate's lipophilicity and molecular size, then watch it circulate in a bloodstream and either diffuse through the tightly-sealed BBB into brain tissue or bounce off, compared side-by-side with a normal leaky capillary.

Medicine & Biophysics3DModerate60 FPS

Watch a drug candidate circulate through two vessel types at once: an ordinary leaky capillary and a tightly-sealed brain capillary protected by the blood-brain barrier. Tune lipophilicity and molecular size to see which molecules diffuse through the BBB's cell membranes into brain tissue, and which are turned back — even though the very same molecule crosses the ordinary vessel freely.

⚙ Under the hood

Tune a drug candidate's lipophilicity and molecular size, then watch it circulate through a 3D bloodstream and either diffuse through the tightly-sealed blood-brain barrier into brain tissue or bounce off, compared side-by-side against a normal leaky capillary the same molecule crosses freely.

blood-brain barrierneuropharmacologydrug deliverylipophilicitytight junctionsCNS drug penetrationmolecular diffusionpharmacokinetics

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install