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PBPK Multi-Organ Drug Distribution Simulator

Physiologically-based pharmacokinetic (PBPK) simulator: watch a bolus drug dose flow from blood into the liver, kidney, fat and the rest of the body, driven by real blood-flow-limited compartment equations, tissue partition coefficients, and hepatic/renal clearance.

Medicine & Biophysics3DAdvanced60 FPS📱 Mobile-adapted⇄ 2D version

A physiologically-based pharmacokinetic (PBPK) model of a single IV bolus dose as it circulates through the body: blood is pumped to the liver, kidney, fat and the rest of the body at each organ's real fraction of cardiac output, each tissue equilibrates with blood through a drug-specific partition coefficient, and hepatic and renal clearance permanently remove drug from the liver and kidney compartments. Adjust the dose, the drug's lipophilicity, and CYP450/renal clearance to see how a hydrophilic drug stays confined to blood while a lipophilic one is sequestered — and slowly released — by fat, with every organ's live concentration tracked numerically alongside the flowing 3D circulation.

⚙ Under the hood

A physiologically-based pharmacokinetic (PBPK) model where an IV bolus dose circulates through blood, liver, kidney, fat and the rest of the body, driven by real blood-flow-limited compartment equations, tissue partition coefficients, and hepatic/renal clearance.

pharmacokineticsPBPKpharmacologyclearancedrug distributioncompartment model

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install