Lifespan Pharmacokinetics: Pediatric & Geriatric Dosing

This simulator drives a real one-compartment pharmacokinetic model — C(t) = (Dose/Vd)·e^(−(CL/Vd)t) — with age-dependent clearance and volume-of-distribution curves built from the physiology that pharmacology students actually learn: immature renal filtration and hepatic enzymes at birth, a childhood window where per-kilogram hepatic clearance can exceed adult levels, a stable adult plateau, and a return to reduced renal and hepatic function plus expanded volume of distribution in old age. Slide the age control from neonate to elderly, switch between a renally-cleared and a hepatically-cleared drug, and watch the live 3D concentration curve and the particle-density "compartment" respond in real time, with peak concentration, half-life, clearance and volume of distribution updating instantly and a status readout flagging sub-therapeutic or toxic peaks. Snapshot a curve to freeze it as a ghost trace and compare two ages side by side — a direct illustration of why the same weight-based dose is not safe across the full human lifespan.