Lifespan Pharmacokinetics: Pediatric & Geriatric Dosing (2D)

This simulator drives a real one-compartment pharmacokinetic model, numerically integrating dC/dt = -(CL/Vd)·C on a 2D canvas, with age-dependent clearance and volume-of-distribution curves built from the physiology that pharmacology students actually learn: immature renal filtration and hepatic enzymes at birth, a childhood window where per-kilogram hepatic clearance can exceed adult levels, a stable adult plateau, and a return to reduced renal and hepatic function plus expanded volume of distribution in old age. Slide the age control from neonate to elderly, switch between a renally-cleared and a hepatically-cleared drug, and watch the live concentration curve respond in real time, with peak concentration, half-life, clearance and volume of distribution updating instantly and a status readout flagging sub-therapeutic or toxic peaks. Overlay infant, adult and elderly curves side by side at the same mg/kg dose, or snapshot any single curve as a ghost trace — a direct illustration of why the same weight-based dose is not safe across the full human lifespan.