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Receptor Antagonism 2D: Competitive vs Non-Competitive

Interactive 2D receptor-occupancy simulator: titrate an agonist and an antagonist against a pannable, zoomable bed of membrane receptors and watch a competitive antagonist shift the EC50 while a non-competitive antagonist caps the maximum effect, with a live dose-response curve panel.

Medicine & Biophysics2DModerate60 FPS📱 Mobile-adapted⇄ 3D version

A pannable, zoomable bed of membrane receptors is drawn in 2D, each one recolored moment-to-moment by occupancy theory as you titrate an agonist against an antagonist. Switch the antagonist between competitive (it fights the agonist for the same binding site, shifting the apparent EC50 to the right while the maximum effect stays the same) and non-competitive (it binds a separate allosteric site and silences receptors outright, capping E_max without moving the EC50) and watch both the receptor population and a live dose-response curve respond exactly as the underlying equations predict.

⚙ Under the hood

Titrate an agonist against a competitive or non-competitive antagonist on a pannable, zoomable 2D bed of membrane receptors and watch the dose-response curve shift its EC50 or cap its Emax exactly as receptor occupancy theory predicts.

pharmacologyreceptor bindingdose-responsemedicineagonistantagonist

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install