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Therapeutic Index & Antidote Lab

Compare a wide-margin drug against a narrow-margin drug as dose rises, then overdose the narrow drug and watch a competitive-antagonist antidote displace it off the receptor and reverse toxicity.

Medicine & Biophysics3DModerate60 FPS

A drug's therapeutic index is the ratio between the dose that causes toxic effects and the dose needed for the desired therapeutic effect. This simulator plots that ratio directly: raise a shared dose slider and watch a wide-margin drug stay safely under its toxic threshold across a huge dose range while a narrow-margin drug crosses into toxicity after only a small increase. Switch to the overdose scene to see why some narrow-index drugs — opioids among them — can still be rescued: a competitive-antagonist antidote binds the very same receptor without producing an effect of its own, physically displacing the toxic drug off the binding sites as its dose rises.

⚙ Under the hood

Push a shared dose slider and watch a wide-margin drug stay safely below its toxic threshold across a huge dose range while a narrow-margin drug crosses into toxicity after only a small increase, then switch to an overdose scene where a competitive-antagonist antidote visibly displaces the toxic drug off receptor binding sites and reverses toxicity.

therapeutic indextoxicologypharmacologycompetitive antagonistantidoteoverdose reversalreceptor bindingdose-response curvesafety marginmedicine

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install