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LNP Gene-Editing Delivery to Hepatocytes (2D)

Interactive 2D top-down simulator of lipid-nanoparticle (LNP) delivery of gene-editing cargo to liver hepatocytes: tune ionizable-lipid pKa, N/P charge ratio and particle size to watch fenestral uptake, endosomal escape and cytosolic payload release play out in real time. Drag to pan and scroll to zoom the sinusoid-to-hepatocyte view.

Rare Disease & Gene Therapy2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

This 2D top-down companion to the 3D LNP delivery simulator runs the identical two-stage probability model — fenestral sieving by particle size, then pH-dependent lipid protonation deciding endosomal escape — seen from directly above the sinusoid-to-hepatocyte path. Particles flow through the sinusoid, a fraction slip through the liver's fenestrae to reach the hepatocyte, get trapped in an acidifying endosome, and each one's fate (cytosolic escape or lysosomal degradation) is decided by the same ionizable-lipid chemistry real formulators tune. Adjust the ionizable lipid's pKa, the N/P charge ratio and particle size to see fenestral uptake, endosomal escape and overall cytosolic delivery yield respond in real time, drag to pan and scroll to zoom in on individual particles.

⚙ Under the hood

A 2D top-down companion to the 3D LNP delivery simulator: the same two-stage probability funnel — fenestral sieving by particle size, then pH-dependent ionizable-lipid protonation deciding endosomal escape — rendered as a flat sinusoid-to-hepatocyte view. Tune ionizable-lipid pKa, N/P charge ratio and particle diameter to watch fenestral uptake, endosomal escape and cytosolic delivery yield update live, and drag/scroll to pan and zoom on individual particles.

lipid nanoparticlegene therapydrug deliveryhepatocyteendosomal escapemRNA

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install