🍄 MDMA Cardiovascular & Hyperthermia Risk Monitoring Simulator

Baseline Vitals Before Dosing

Resting heart rate, blood pressure and temperature are captured first.

• 60–80: Resting HR (bpm, healthy adult)
• 120/80: Resting BP (mmHg, typical)
• 36.5–37.2: Core temp (°C, normal range)
• Low: Strain level (no sympathetic load)

Why a baseline matters

A pre-dose baseline anchors every later comparison point.

Placeholder: baseline recording is a short standard first step.

Onset of Sympathetic Activation

Norepinephrine and serotonin release begin raising heart rate.

• 20–40 min: Onset window (typical oral onset)
• +15–25: HR rise (bpm above baseline)
• +10–20: BP rise (mmHg systolic)
• Moderate: Strain level (rising sympathetic tone)

Early sympathetic signs

Placeholder: early activation raises heart rate gradually.

Placeholder: monitor for early tachycardia and rising BP.

Peak Heart Rate and Blood Pressure Elevation

Peak plasma concentration drives maximum cardiovascular load.

• ~90–120 min: Peak time (post-dose window)
• 120–160: Peak HR (bpm possible)
• 150–190: Peak systolic (mmHg possible)
• High: Strain level (sustained cardiac load)

Peak physiological demand

Placeholder: peak load stresses heart and vasculature together.

Placeholder: this window carries the highest cardiac risk.

Hyperthermia Risk Monitoring

Core temperature can climb sharply with heat and exertion.

• ≥39.5°C: Danger threshold (hyperthermia zone)
• Ambient heat: Contributing factor (crowded, hot venues)
• Physical activity: Contributing factor (prolonged dancing)
• Variable: Risk status (depends on environment)

Environmental amplifiers

Placeholder: heat and exertion amplify temperature rise sharply.

Placeholder: hyperthermia is a leading serious complication risk.

Cooling and Recovery Protocol

Active cooling and rest allow vitals to normalize gradually.

• 3–6 hrs: Recovery window (gradual normalization)
• Passive/active: Cooling method (fans, fluids, rest)
• Gradual: HR normalization (returns toward baseline)
• Declining: Strain level (load tapers off)

Supporting safe recovery

Placeholder: cooling and hydration support gradual vital recovery.

Placeholder: continued monitoring is advised into recovery.