🍄 MDMA-Assisted Therapy for PTSD Simulator

Preparatory Non-Drug Therapy Sessions

Placeholder: two non-drug sessions build the therapeutic alliance first.

• 2–3: Prep sessions (Placeholder short caption)
• 90 min: Session length (Placeholder short caption)
• Dyad: Co-therapist model (Placeholder short caption)
• MAPS: Protocol source (Placeholder short caption)

Building trust before dosing

Placeholder: preparatory sessions establish rapport and set intentions.

First MDMA Dosing Session

Placeholder: an 8-hour supervised session with a divided dose.

• 80–120mg: Initial dose (Placeholder short caption)
• 40–60mg: Booster dose (Placeholder short caption)
• ~8 hrs: Session duration (Placeholder short caption)
• Continuous: Monitoring (Placeholder short caption)

Supervised dosing conditions

Placeholder: vitals and affect monitored throughout the session.

Reduced Fear Response Window

Placeholder: amygdala reactivity drops, easing fear-based avoidance.

• ↓ reduced: Amygdala activity (Placeholder short caption)
• ↑ increased: Trust / bonding (Placeholder short caption)
• ↓ reduced: Defensiveness (Placeholder short caption)
• ~4–6 hrs: Window duration (Placeholder short caption)

A neurobiological window opens

Placeholder: reduced fear response allows safer trauma engagement.

Trauma Processing With Therapist

Placeholder: patient revisits traumatic memories with guided support.

• Guided: Processing mode (Placeholder short caption)
• 3 per dose: Integration sessions (Placeholder short caption)
• Active: Memory reconsolidation (Placeholder short caption)
• Non-directive: Therapist role (Placeholder short caption)

Working through trauma memories

Placeholder: memories are revisited and reframed with support.

Placeholder key insight: processing occurs within the open window.

CAPS-5 Score Improvement Across Sessions

Placeholder: PTSD symptom severity declines across three sessions.

• ~50–60%: CAPS-5 reduction (Placeholder short caption)
• ~67%: Remission rate (Placeholder short caption)
• 12 months: Follow-up (Placeholder short caption)
• Phase 3: Trial phase (Placeholder short caption)

Trajectory of symptom relief

Placeholder: scores trend downward with each processed session.