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Chromatin Remodeler: Nucleosome Sliding Simulator

Interactive 3D simulation of ATP-dependent chromatin remodeling: watch SWI/SNF- and ISWI-family motor complexes reposition nucleosomes along DNA, either spacing them evenly or clearing a promoter to open a nucleosome-depleted region.

Molecular Biology3DAdvanced60 FPS📱 Mobile-adapted⇄ 2D version

Nucleosomes are not fixed in place — ATP-powered chromatin remodeling complexes actively reposition them along the DNA fiber. This simulator renders a chromatin fiber as a chain of histone octamers wrapped in double-stranded DNA and lets you switch between two real remodeling behaviours: an ISWI/CHD1-style "spacing" motor that senses linker DNA on each side of a nucleosome and equalizes it, and a SWI/SNF/RSC-style motor that pushes nucleosomes away from a marked promoter window to open a nucleosome-depleted region. Tune the ATP turnover rate and the number of simultaneously active remodeler complexes, and watch live readouts of promoter accessibility, mean linker length and total ATP cycles consumed as the fiber reorganizes one discrete, collision-constrained step at a time.

⚙ Under the hood

Watch ATP-dependent chromatin remodeling complexes reposition nucleosomes along DNA in real time, either spacing them evenly like ISWI/CHD1 or clearing a promoter window like SWI/SNF to open a nucleosome-depleted region.

chromatin remodelingnucleosomeSWI/SNFISWIepigeneticshistone

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install