Exon-Skipping ASO Reading-Frame Repair

Duchenne muscular dystrophy is usually caused by a dystrophin gene deletion that throws the ribosome's reading frame out of register, producing a premature stop codon and no protein. This simulator models the real arithmetic behind splice-switching antisense-oligonucleotide therapy (the eteplirsen/exon-51 class of drugs): pick a patient's exon deletion genotype, dose an ASO that forces the spliceosome to additionally skip exon 51, and watch whether the combined length of everything removed lands back on a multiple of three. A 3D ribosome translates the resulting mRNA codon-by-codon, building a polypeptide chain that either runs to completion (frame restored, Becker-like functional protein) or halts at a premature stop (frame still broken, transcript flagged for nonsense-mediated decay) — with a live population strip showing what fraction of transcripts across many molecules are rescued at the current ASO dose.