Telomere T-Loop Capping & DNA Damage Checkpoint (2D)
Interactive 2D model of a chromosome end: watch shelterin proteins fold telomeric DNA into a protective T-loop, shorten the telomere below the critical length, and see the exposed end trigger the DNA-damage checkpoint that drives replicative senescence — with a live division-count-to-senescence statistic checked against a formula.
This simulator draws one chromosome end in 2D and models the molecular decision that underlies replicative senescence: can the shelterin complex still fold the telomere into a protective T-loop? Set the double-stranded telomere length and shelterin availability, then trigger cell divisions — each one shortens the telomere through the end-replication problem — and watch the T-loop's stability fall, the DNA-damage response climb, and the cell cross over into senescence once the chromosome end can no longer be hidden from the repair machinery. A population panel runs thousands of independent lineages through the same rule and checks the measured average division-count-to-senescence against a closed-form formula.
Watch a chromosome end fold into a protective T-loop as shelterin proteins cap it — shorten the telomere below the critical length and the exposed DNA end triggers the DNA-damage checkpoint that drives the cell into replicative senescence.
2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install