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Huntingtin PolyQ Nucleated Aggregation (2D)

Interactive 2D nucleated-polymerization model of huntingtin polyglutamine (polyQ) aggregation: tune the CAG-repeat length and watch a stochastic nucleation-elongation process produce the characteristic lag-then-rapid-growth sigmoid kinetics.

Molecular Biology2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

This 2D twin of the huntingtin polyglutamine (polyQ) nucleation-elongation model drives the same length-dependent nucleated-polymerization kinetics as the 3D version — sub-critical monomer addition is slow, addition above the critical nucleus size is fast — from an explicit stochastic size-dependent rate function rather than any fitted sigmoid. A reaction-vessel view shows free monomers diffusing and being captured onto a single growing aggregate; a live plot tracks aggregate fraction versus time, and a built-in repeat-length sweep measures how the lag phase shortens as the simulated CAG-repeat length increases, reproducing the disease-severity correlation seen in Huntington's disease.

⚙ Under the hood

Interactive 3D nucleated-polymerization model of huntingtin polyglutamine (polyQ) aggregation: tune the CAG-repeat length past the pathogenic threshold and watch monomers nucleate and elongate into amyloid-like fibrils.

huntingtinpolyglutamineamyloidprotein-aggregationnucleationneurodegeneration

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install