Lysosomal Membrane Damage: 2D Sector-Field Model

This 2D companion to the 3D "Trojan horse" nanotoxicology simulator keeps the same underlying physics — Stokes–Einstein Brownian diffusion of trapped nanoparticles, dose- and reactivity-dependent membrane damage, and a stochastic pore-nucleation threshold — but computes it independently with a genuinely 2D-native model: instead of one scalar damage number for the whole membrane, the lysosome's cross-section is divided into 48 independent angular sectors, each accumulating damage only from the nanoparticle contacts that actually land in it. The result is spatially heterogeneous, patchy membrane failure — the first sector to cross the rupture threshold nucleates its own pore and releases cathepsins from that exact location, while the rest of the membrane can remain intact. An unrolled damage-by-angle strip beneath the disk view, with no equivalent in the 3D simulator, makes this localization directly visible as it develops.