Huntingtin PolyQ Nucleated Aggregation

This simulator models the nucleation-elongation kinetics behind huntingtin polyglutamine (polyQ) aggregation, the molecular process underlying Huntington's disease. A pool of monomers undergoes Brownian motion inside a 3D volume; when enough of them transiently cluster they can form a critical nucleus at a rate that depends steeply on the simulated CAG-repeat length, reproducing the sharp pathogenic threshold observed experimentally around 36–39 repeats. Once nucleated, monomers are captured onto the growing fibril end, and live readouts track free-monomer count, fibril count, the longest fibril, and the fraction of the pool that has aggregated.