HomeMolecular BiologyHelix-Coil Transition: Space-Time & Melting Map

Helix-Coil Transition: Space-Time & Melting Map

Interactive 2D helix-coil transition simulator: the same Zimm-Bragg-style Metropolis Monte-Carlo model of alpha-helix i,i+4 hydrogen bonding drawn as a scrolling residue space-time map plus a live analytic melting curve, instead of a 3D backbone.

Molecular Biology2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version
2d-biochemistry-chemistry-2 ↗ Open standalone

This simulator runs the identical coarse-grained Metropolis Monte-Carlo model of alpha-helix formation as its 3D counterpart — a Zimm–Bragg-style nucleation-plus-propagation free energy over a peptide's coil/helix flags — but drops the folded backbone entirely in favor of two genuinely 2D representations. A scrolling space-time map turns every Monte-Carlo sweep into one new row of a residue-by-time heatmap, so nucleation and cooperative growth are visible directly as a spreading pattern rather than inferred from a rotating 3D shape. Alongside it, a live melting-curve panel plots the exact single-dominant-domain analytic equilibrium helix content against temperature and marks where the running simulation currently sits, so you can watch the simulated state track (or lag) the theoretical curve as you sweep temperature, chain length and sequence.

⚙ Under the hood

The same Zimm-Bragg-style Metropolis Monte-Carlo model of alpha-helix i,i+4 hydrogen-bond cooperativity as the 3D backbone simulator, rendered as a scrolling residue space-time heatmap next to a live analytic helix-content-vs-temperature melting curve, instead of a folded 3D structure.

alpha helixhelix-coil transitionZimm-Braggprotein foldingMonte Carlohydrogen bondingmelting curve

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install

What did you find?

Add reproduction steps (optional)