Home▸Medical Technology & Imaging Physics▸Tubuloglomerular Feedback: How Each Kidney Nephron Self-Regulates

🧫 Tubuloglomerular Feedback: How Each Kidney Nephron Self-Regulates

Explore tubuloglomerular feedback, the local self-regulating loop where macula densa cells sense sodium chloride and adjust afferent arteriole tone to keep each nephron's filtration rate stable.

Medical Technology & Imaging Physics3DModerate60 FPS

This simulator demonstrates how a single nephron senses sodium chloride delivery at its macula densa and adjusts afferent arteriole tone through adenosine signaling to keep its own glomerular filtration rate stable.

🔬 What It Demonstrates

🎮 How to Use

Adjust blood pressure, tubular flow, or sodium reabsorption sliders and watch the macula densa signal, adenosine release, and afferent arteriole diameter respond in real time to bring filtration rate back toward its target.

💡 Did You Know?

Each of the roughly one million nephrons in a kidney runs this feedback loop independently, meaning the kidney is really a parallel network of tiny autonomous regulators rather than one centrally controlled organ.

⚙ Under the hood

Explore tubuloglomerular feedback, the local self-regulating loop where macula densa cells sense sodium chloride and adjust afferent arteriole tone to keep each nephron's filtration rate stable.

nephrologykidney physiologymacula densagfr regulationrenal autoregulationadenosine signalingdiabetic kidney diseasenephron

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install