Home▸Medical Technology & Imaging Physics▸The Male HPG Axis: Testosterone's Feedback Loop

🧬 The Male HPG Axis: Testosterone's Feedback Loop

Explore how the hypothalamus, pituitary, and testes work together in a tightly regulated feedback loop to control testosterone production and sperm formation in men.

Medical Technology & Imaging Physics3DModerate60 FPS

This simulator demonstrates how GnRH, LH, FSH, testosterone, and inhibin interact through a closed-loop feedback system to regulate male hormone production and fertility.

🔬 What It Demonstrates

This simulator demonstrates how GnRH, LH, FSH, testosterone, and inhibin interact through a closed-loop feedback system to regulate male hormone production and fertility.

🎮 How to Use

Adjust hormone inputs or introduce exogenous testosterone to see in real time how the hypothalamus, pituitary, and testes respond and rebalance across the feedback loop.

💡 Did You Know?

Continuous, non-pulsatile GnRH exposure actually suppresses the pituitary rather than stimulating it, which is the exact mechanism doctors exploit with GnRH agonist medications.

⚙ Under the hood

Explore how the hypothalamus, pituitary, and testes work together in a tightly regulated feedback loop to control testosterone production and sperm formation in men.

endocrinologytestosteronehpg-axishormonesphysiologyreproductive-healthmale-healthbiology

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install