This simulator demonstrates how GnRH, LH, FSH, testosterone, and inhibin interact through a closed-loop feedback system to regulate male hormone production and fertility.
Adjust hormone inputs or introduce exogenous testosterone to see in real time how the hypothalamus, pituitary, and testes respond and rebalance across the feedback loop.
Sliders let you control GnRH pulse frequency and exogenous testosterone dosing to observe downstream changes in LH, FSH, testosterone, and inhibin levels.
Continuous, non-pulsatile GnRH exposure actually suppresses the pituitary rather than stimulating it, which is the exact mechanism doctors exploit with GnRH agonist medications.
This simulator demonstrates how GnRH, LH, FSH, testosterone, and inhibin interact through a closed-loop feedback system to regulate male hormone production and fertility.
This simulator demonstrates how GnRH, LH, FSH, testosterone, and inhibin interact through a closed-loop feedback system to regulate male hormone production and fertility.
Adjust hormone inputs or introduce exogenous testosterone to see in real time how the hypothalamus, pituitary, and testes respond and rebalance across the feedback loop.
Continuous, non-pulsatile GnRH exposure actually suppresses the pituitary rather than stimulating it, which is the exact mechanism doctors exploit with GnRH agonist medications.