MIC vs. Achievable Site Concentration
Compare a bacterial strain's Minimum Inhibitory Concentration (MIC) against the antibiotic concentration actually achievable at an infection site (dose × tissue-penetration factor) — watch the same strain clear at an easy-to-penetrate site like urine while persisting at a hard-to-penetrate one like the brain/CSF.
Pick a bacterial strain's Minimum Inhibitory Concentration, a prescribed antibiotic dose and an infection site, and watch whether the concentration the drug actually reaches at that site clears or fails to clear the same colony — because a lab-measured MIC only predicts treatment success once it's compared against what's actually achievable in that specific tissue.
Pick a bacterial strain's Minimum Inhibitory Concentration, an antibiotic dose and an infection site, and watch whether the concentration the drug actually achieves there clears or fails the same colony — a low-MIC strain can be clinically untreatable at a hard-to-penetrate site like the brain/CSF while a higher-MIC strain still clears easily in urine.
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