HomeMedicine & BiophysicsBeta-Cell Compensation: The Diabetes Tipping Point

Beta-Cell Compensation: The Diabetes Tipping Point (2D)

Interactive 2D model of pancreatic beta-cell mass compensating for rising insulin resistance: set the rate of resistance progression and watch live glucose and beta-cell-function curves hold a long compensated plateau before tipping sharply into decompensated type 2 diabetes.

Medicine & Biophysics2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version
2d-medicine-topic-32 ↗ Open standalone

This simulator renders the same real systems-biology model of type 2 diabetes onset as the 3D version — a fast glucose–insulin feedback loop nested inside a slow pancreatic beta-cell function equation — but drives it with an explicit, user-controlled insulin-resistance progression rate instead of a static sensitivity dial, and plots the result as live glucose-vs-time and beta-cell-function-vs-time curves on a 2D canvas. Push the progression rate up and watch the long, flat compensated plateau shrink and the tipping point arrive sooner; once glucose crosses the glucotoxic threshold, beta-cell function's decline visibly steepens as the runaway feedback takes hold.

⚙ Under the hood

A systems-biology model of type 2 diabetes onset: tune insulin sensitivity, beta-cell regeneration capacity and glucotoxicity, and watch a live 3D pancreatic islet either compensate for insulin resistance or tip into runaway glucotoxic collapse.

diabetesbeta-cellsinsulin-resistancesystems-biologybifurcationendocrinology

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install

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