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Saturable First-Pass Metabolism — 2D Sinusoid Concentration Profile

Interactive 2D simulator of capacity-limited (Michaelis-Menten) hepatic first-pass metabolism using the spatially-resolved parallel-tube model: watch drug concentration decay continuously along the liver sinusoid and compare its extraction ratio live against the classic well-stirred model.

Medicine & Biophysics2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

Details

CategoryMedicine & Biophysics

RenderingCanvas 2D

DifficultyAdvanced

Target FPS60

ControlsDrag sliders for entering dose concentration, enzyme metabolic capacity, affinity constant and hepatic blood flow to watch the concentration profile decay continuously along the sinusoid and the enzyme-occupancy heat strip respond in real time. Press Reset Molecule Stream to clear the flowing particles. The side panel plots bioavailability vs. dose for both the parallel-tube model and the well-stirred reference model, marked at the current dose.

pharmacokineticshepatic-metabolismmichaelis-mentenbioavailabilitycyp450dose-responseparallel-tube-modelspatial-pharmacokinetics

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The 3D flagship version of this simulator models the liver as a single well-stirred compartment. This 2D companion solves the alternate, spatially-resolved parallel-tube model of hepatic clearance: a genuine one-dimensional advection-reaction ODE integrated numerically (RK4) along the length of the sinusoid, rendered as a continuously decaying concentration profile rather than a lumped algebraic extraction ratio. Adjust the entering dose concentration, enzyme capacity, binding affinity and hepatic blood flow to watch the concentration curve, the enzyme-occupancy heat strip, and a live-flowing stream of drug molecules all respond to the same underlying Michaelis-Menten saturation — and compare the parallel-tube extraction ratio directly against the classic well-stirred prediction on the same panel.

⚙ Under the hood

A 2D simulator of capacity-limited (Michaelis-Menten) hepatic first-pass metabolism using the spatially-resolved parallel-tube model: a genuine 1D advection-reaction ODE is integrated numerically along the liver sinusoid, showing drug concentration decay continuously as CYP450 enzyme sites saturate, with the extraction ratio compared live against the classic well-stirred (venous equilibrium) model.

pharmacokineticshepatic-metabolismmichaelis-mentenbioavailabilitycyp450dose-responseparallel-tube-modelspatial-pharmacokinetics

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install