HomeMedicine & BiophysicsEnzyme Saturation & Drug Metabolism Simulator

Enzyme Saturation & Drug Metabolism Simulator

Interactive Michaelis-Menten drug-metabolism simulator: raise the dose and watch a fixed pool of liver enzymes saturate, the metabolism-rate curve flatten at Vmax, and blood drug concentration shift from proportional (first-order) to dangerously unbounded (zero-order) accumulation.

Medicine & Biophysics3DModerate60 FPS
enzyme-saturation-drug-metabolism-simulator ↗ Open standalone

Liver enzymes such as cytochrome P450 have a finite number of active sites available to metabolize a drug at any instant. This simulator models that pool directly: raise the dose slider and watch a fixed cluster of 3D enzyme sites shift from mostly free (low dose) to almost entirely occupied (high dose), while the metabolism-rate curve on the right rises then flattens at its maximum, Vmax, and the concentration-over-time trace shows blood levels settling to a proportional steady state below saturation — or climbing without bound once dose exceeds the enzyme system's maximum clearance capacity.

⚙ Under the hood

Raise a drug dose and watch a fixed pool of liver enzyme active sites saturate: the Michaelis-Menten metabolism-rate curve rises then flattens at Vmax, and steady-state blood concentration shifts from proportional (first-order) below saturation to dangerously unbounded (zero-order) once dose exceeds the enzyme system's maximum clearance capacity.

michaelis-mentenenzyme saturationdrug metabolismvmaxzero-order kineticsfirst-order kineticspharmacokineticscytochrome p450

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install

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