HomeMedicine & BiophysicsStereocilia Tip-Link Gating Spring

Stereocilia Tip-Link Gating Spring (2D)

Interactive 2D model of cochlear hair-cell mechanotransduction: deflect a pair of stereocilia, watch the tip-link spring stretch and gate a MET ion channel, and read the live Boltzmann open-probability curve.

Medicine & Biophysics2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version
2d-cochlear-hair-cell-mechanotransduction ↗ Open standalone

Cochlear hair cells convert mechanical motion into electricity through a single elegant mechanism: the tip link. This 2D simulator isolates one adjacent stereocilia pair, deflects it under your control, and computes the real tip-link extension, its tension, the Boltzmann open probability of the mechanotransduction channel it gates, and the resulting receptor current — all from the same gating-spring equations used in cochlear biophysics, plotted live against the deflection axis. A slow adaptation motor continuously resets the channel's operating point, reproducing the characteristic overshoot-and-relax response real hair cells show to a sustained deflection.

⚙ Under the hood

Deflect a 3D stereocilia bundle and watch tip-link tension gate mechanotransduction channels through the Boltzmann gating-spring model, with a live adaptation motor and receptor-current readout.

hair cellmechanotransductionstereociliabiophysicscochleaion channel

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install

What did you find?

Add reproduction steps (optional)