💉 Ketamine Bladder & Hepatotoxicity Long-Term Risk Simulator

Single-Course Baseline Exposure

A single short ketamine course leaves bladder and liver near normal.

• ~3mm: Wall thickness (normal reference range)
• None: Cystitis signs (placeholder baseline)
• Normal: Liver enzymes (placeholder baseline)
• Annual: Monitoring (placeholder cadence)

Baseline tissue status

Placeholder: single-course exposure shows minimal tissue change.

Cumulative Bladder Wall Changes

Repeated courses drive progressive bladder wall thickening.

• Rising: Wall thickness (placeholder trend)
• Emerging: Fibrosis signal (placeholder marker)
• Gradual: Capacity loss (placeholder marker)
• Partial: Reversibility (placeholder note)

Wall thickening dynamics

Placeholder: cumulative courses correlate with wall thickening.

Ketamine-Induced Cystitis Symptoms

Urgency, frequency, and pain markers signal cystitis onset.

• Elevated: Urgency score (placeholder marker)
• Rising: Pain marker (placeholder marker)
• Possible: Hematuria risk (placeholder marker)
• Dose-linked: Symptom onset (placeholder note)

Symptom emergence

Placeholder: cystitis symptoms scale with dose and course count.

Liver Enzyme Elevation Tracking

Cumulative exposure raises hepatic enzyme elevation markers.

• Rising: ALT marker (placeholder trend)
• Rising: AST marker (placeholder trend)
• Possible: Cholestasis signal (placeholder note)
• High: Dose sensitivity (placeholder note)

Hepatic marker trend

Placeholder: enzyme elevation risk tracks cumulative dose exposure.

Long-Term Monitoring Protocol

Scheduled checkpoints track bladder and liver status over time.

• Course-based: Checkpoint interval (placeholder cadence)
• Periodic: Bladder imaging (placeholder cadence)
• Periodic: Liver panel (placeholder cadence)
• Symptom-based: Escalation trigger (placeholder note)

Monitoring cadence

Placeholder: monitoring frequency scales with lifetime course count.