💉 IV Ketamine Infusion Protocol for Depression Simulator

Establishing Baseline Severity Before Ketamine Induction

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• MADRS: Primary scale (Short placeholder note.)
• ≤7 days: Screening window (Short placeholder note.)
• Psychosis hx: Exclusion check (Short placeholder note.)
• BP/HR: Baseline vitals (Short placeholder note.)

Screening and baseline severity scoring

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Weight-Based Dosing at 0.5 mg/kg Racemic Ketamine

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• 0.5 mg/kg: Standard dose (Short placeholder note.)
• 100 mL NS: Diluent volume (Short placeholder note.)
• 40 min: Pump rate (Short placeholder note.)
• ~60 mg: Max single dose (Short placeholder note.)

Calculating and preparing the infusion dose

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40-Minute Continuous IV Infusion With Vital Monitoring

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• 40 min: Infusion length (Short placeholder note.)
• Every 5 min: Vitals interval (Short placeholder note.)
• ~30 min: Post-obs time (Short placeholder note.)
• CADSS: Dissociation tool (Short placeholder note.)

Vital sign and dissociation monitoring protocol

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Six Infusions Scheduled Across Two to Three Weeks

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• 6 infusions: Course length (Short placeholder note.)
• 2–3 weeks: Course duration (Short placeholder note.)
• 2–3x/week: Typical frequency (Short placeholder note.)
• Tracked: Cumulative dose (Short placeholder note.)

Spacing and tracking the induction course

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Scoring Response and Planning Maintenance Infusions

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• ≥50% drop: Response cutoff (Short placeholder note.)
• MADRS ≤10: Remission cutoff (Short placeholder note.)
• q2–4 wks: Maintenance freq (Short placeholder note.)
• Ongoing: Relapse watch (Short placeholder note.)

Assessing response and scheduling maintenance care

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Short placeholder callout about durability of response and maintenance dosing.