Single-Course Baseline Exposure
A single short ketamine course leaves bladder and liver near normal.
- ~3mm: Wall thickness (normal reference range)
- None: Cystitis signs (placeholder baseline)
- Normal: Liver enzymes (placeholder baseline)
- Annual: Monitoring (placeholder cadence)
Baseline tissue status
Placeholder: single-course exposure shows minimal tissue change.
Cumulative Bladder Wall Changes
Repeated courses drive progressive bladder wall thickening.
- Rising: Wall thickness (placeholder trend)
- Emerging: Fibrosis signal (placeholder marker)
- Gradual: Capacity loss (placeholder marker)
- Partial: Reversibility (placeholder note)
Wall thickening dynamics
Placeholder: cumulative courses correlate with wall thickening.
Ketamine-Induced Cystitis Symptoms
Urgency, frequency, and pain markers signal cystitis onset.
- Elevated: Urgency score (placeholder marker)
- Rising: Pain marker (placeholder marker)
- Possible: Hematuria risk (placeholder marker)
- Dose-linked: Symptom onset (placeholder note)
Symptom emergence
Placeholder: cystitis symptoms scale with dose and course count.
Liver Enzyme Elevation Tracking
Cumulative exposure raises hepatic enzyme elevation markers.
- Rising: ALT marker (placeholder trend)
- Rising: AST marker (placeholder trend)
- Possible: Cholestasis signal (placeholder note)
- High: Dose sensitivity (placeholder note)
Hepatic marker trend
Placeholder: enzyme elevation risk tracks cumulative dose exposure.
Long-Term Monitoring Protocol
Scheduled checkpoints track bladder and liver status over time.
- Course-based: Checkpoint interval (placeholder cadence)
- Periodic: Bladder imaging (placeholder cadence)
- Periodic: Liver panel (placeholder cadence)
- Symptom-based: Escalation trigger (placeholder note)
Monitoring cadence
Placeholder: monitoring frequency scales with lifetime course count.