Home▸Glycobiology & Glycan Engineering▸Calnexin/Calreticulin Cycle: N-Glycan Quality Control

Calnexin/Calreticulin Cycle: N-Glycan Quality Control (2D)

Interactive 2D diagram of the ER glycoprotein quality-control checkpoint: monoglucosylated N-glycans bind calnexin/calreticulin, UGGT re-glucosylates misfolded proteins for another try, and a live histogram tracks the geometric-distribution spread of exit times across many proteins.

Glycobiology & Glycan Engineering2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

Every glycoprotein made in the endoplasmic reticulum has to pass a single molecular checkpoint before it is allowed to leave: repeated binding to the lectin chaperones calnexin and calreticulin, gated by the glucose residues on its N-glycan. This 2D diagram renders that cycle top-down — proteins arrive at the ER membrane, get trimmed to the monoglucosylated binding signal, dock at a chaperone site, and either fold and exit to the Golgi or get re-glucosylated by UGGT for another attempt. Persistent failures are mannose-trimmed and diverted to ERAD. Tune the folding probability, the ERAD cycle threshold, the protein influx rate and the number of chaperone slots, watch the exported/degraded counts update live, and read the round-count histogram to see the geometric distribution of exit times build up across many independently simulated proteins.

⚙ Under the hood

Watch the ER glycoprotein quality-control checkpoint run in 2D: monoglucosylated N-glycans bind calnexin/calreticulin for a folding attempt, UGGT re-glucosylates failures for another try, and proteins that exceed the cycle threshold are mannose-trimmed and routed to ERAD.

glycobiologyER quality controlcalnexinprotein foldingERADN-glycans

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install