Spatial Neighborhood Enrichment Explorer (2D)

Spatial multi-omics turns a tissue section into a map of individually typed cells, and the central question pathologists ask of that map is not "how many" but "who sits next to whom." This 2D top-down companion generates the same synthetic multiplexed tissue section — tumor, T-cell, macrophage and stroma cells — lets you pan and zoom the field by hand, dial the immune infiltration fraction and T-cell clustering strength around the tumor margin, and then runs a real label-permutation neighborhood-enrichment test on the resulting spatial graph, with the null distribution drawn live as a histogram so the z-score's meaning is visible, not just numeric.