Home▸Chemistry & Materials▸Solid-Phase Peptide Synthesis (SPPS) Simulator

🧬 Solid-Phase Peptide Synthesis (SPPS) Simulator

Watch Merrifield solid-phase peptide synthesis (SPPS) build a peptide chain on a resin bead, cycle by cycle: Fmoc deprotection (piperidine), HBTU/DIC activation, amide-bond coupling, wash, and final TFA cleavage.

Chemistry & Materials3DModerate60 FPS

Details

CategoryChemistry & Materials

RenderingThree.js · WebGL

DifficultyModerate

Target FPS60

ControlsSequence buttons pick a 3-5 residue peptide (Ala-Gly-Ser / Leu-Lys-Asp-Phe / Gly-Pro-Val-Cys-Tyr / Phe-Glu-Arg-Trp); Start synthesis runs the full Fmoc deprotection - activation - coupling - wash cycle per residue then TFA cleavage; animation-speed slider (0.25x-3x); Reset restarts the sequence from the anchored first residue.

Three.jschemistrybiochemistrypeptide synthesisamino acidsSPPSMerrifieldorganic chemistry

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⚙ Under the hood

Merrifield solid-phase peptide synthesis (SPPS) on a 3D resin bead: pick a 3-5 residue sequence and step through the real Fmoc-SPPS cycle - piperidine deprotection, HBTU/DIC activation, amide-bond coupling, DMF wash - then watch TFA cleave the finished peptide off the resin.

Three.jschemistrybiochemistrypeptide synthesisamino acidsSPPSMerrifieldorganic chemistry

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install