HomeCell Line Development & CHO EngineeringImpeller Shear & Mixing Time in Bioreactor Scale-Up

Impeller Shear & Mixing Time in Bioreactor Scale-Up

Interactive stirred-tank bioreactor simulator: tune impeller speed, vessel scale and broth viscosity to see the Kolmogorov microscale shrink toward cell size, watch circulating flow set the mixing time, and track how cell viability collapses when local shear outruns the cells.

Cell Line Development & CHO Engineering3DAdvanced60 FPS
biotech-topic-11 ↗ Open standalone

Bioprocess scale-up looks simple on paper — keep the geometry similar and turn up the impeller — but power draw grows with the cube of speed and the fifth power of impeller diameter, so the same "well-mixed" target at production scale can push local energy dissipation, and the Kolmogorov microscale it sets, far past what shear-sensitive cells can survive. This simulator models a Rushton-turbine stirred tank in 3D: dial in impeller speed, vessel scale and broth viscosity and watch the circulating flow field, the shrinking turbulent microscale, and the resulting cell-viability trade-off, or inject a tracer dye pulse to see the mixing-time estimate play out live.

⚙ Under the hood

Tune impeller speed, vessel scale and broth viscosity on a 3D Rushton-turbine bioreactor to watch the Kolmogorov turbulence microscale shrink toward cell size, and see cell viability and mixing time trade off as the vessel scales from bench to production.

bioreactorshear stressmixing timescale-upCHO cellsturbulence

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install

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