🧫 Cell Line Development & CHO Engineering

Bioreactor Scale-Down Model Qualification (kLa Matching) — 2DNew📱Interactive 2D bioreactor scale-down model: tune bench-scale impeller speed and aeration… Turbulent Shear Cascade in a Bioreactor Slice (2D)New📱A 2D companion to the 3D Rushton-turbine bioreactor sim: instead of a scripted circulation… Impeller Shear & Mixing Time in Bioreactor Scale-UpNew📱Tune impeller speed, vessel scale and broth viscosity on a 3D Rushton-turbine bioreactor to… Bioreactor Scale-Down Model Qualification (kLa Matching)New📱Interactive 3D bioreactor scale-down model: tune bench-scale impeller speed and aeration… CHO Cell Line Clone SelectionNew📱Screening of thousands of CHO cell line clones for recombinant protein expression levels,… Stable Cell Pool Generation (Transfection)New📱Transfection of a plasmid followed by antibiotic selection to establish a stable pool of… Codon Optimization for Recombinant ExpressionNew📱Optimizing the codon usage for maximizing protein yield in CHO cells. Fed-Batch Bioreactor Feeding StrategyNew📱Feeding strategy for fed-batch bioreactors to increase cell density. Glycosylation Profile EngineeringNew📱Engineering the glycosylation profile to enhance the ADCC activity of an antibody. Single-Cell Cloning via FACS/ClonePixNew📱Single-cell cloning using flow cytometry or ClonePix to ensure monoclonality. Cell Culture Media Optimization (DoE)New📱This simulation focuses on designing experiments to optimize the composition of cell culture… Perfusion Bioreactor High-Density CultureNew📱This simulation demonstrates the operation of a perfusion bioreactor for maintaining…